2010 Fiscal Year Final Research Report
Functional analysis of a novel RAD51-binding protein, EVL in the homologous recombinational repair
| Project/Area Number |
21870037
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Waseda University |
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Principal Investigator |
TAKAKU Motoki Waseda University, 理工学術院, 助手 (30547071)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ゲノム構築・機能・維持 / タンパク質と酵素 / 核酸 / 遺伝子及び染色体 |
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| Research Abstract |
EVL promotes ssDNA catenation in the presence of human TOPOIIIα, which is a type I topoisomerase. Therefore EVL and TOPOIIIα may function in the processing of DNA intermediates formed during homologous recombinational repair (HRR). C-terminal EVH2 domain of EVL is responsible for the recombination activity of EVL. RAD51, RPA and TOPOIIIα promote recombination reaction between circular ssDNA and supercoiled dsDNA. It suggests that these proteins cooperatively function in the initial step of HRR.
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[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010
Author(s)
Yoshimasa Takizawa, Yong Qing, Motoki Takaku, Takako Ishida, Yuichi Morozumi, Takashi Tsujita, Toshiaki Kogame, Kouji Hirota, Masayuki Takahashi, Takehiko Shibata, Hitoshi Kurumizaka, Shunichi Takeda
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Journal Title
Nucleic Acids Research Vol.38
Pages: 5059-74
Peer Reviewed
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[Journal Article] The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction2009
Author(s)
Mari Katsura, Takanori Tsuruga, Osamu Date, Takashi Yoshihara, Mari Ishida, Yoshitaka Tomoda, Miyuki Okajima, Motoki Takaku, Hitoshi Kurumizaka, Aiko Kinomura, Hiromu K. Mishima, Kiyoshi Miyagawa
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Journal Title
Nucleic Acids Research Vol.37
Pages: 3959-68
Peer Reviewed
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