2010 Fiscal Year Final Research Report
Function and regulatory mechanism of the microtubule cytoskeleton required for epithelial morphogenesis in vivo
| Project/Area Number |
21870043
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SUZUKI Makoto National Institute for Basic Biology, 形態形成研究部門, 助教 (10533193)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経管閉鎖 / 細胞伸長 / 頂端収縮 |
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| Research Abstract |
To understand the function and regulatory mechanisms of microtubule cytoskeleton in epithelial morphogenesis in vivo, we performed cell biological analyses of neural tube formation in Xenopus and zebrafish embryos. Results presented here showed that correct microtubule organization positively regulates cell elongation, one of the important cellular behaviors in the neuroepithelial cells. We also found that xMID and Mig12 proteins were involved in microtubule-mediated cell elongation. These findings would help us to understand pathological mechanisms of various disorders in human, resulted from the abnormalities in epithelial tissues.
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