2010 Fiscal Year Final Research Report
Study on the molecular mechanism of autophagy at nonfeeding periods in the hard tick Haemaphysalis longicornis
| Project/Area Number |
21880038
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
SHIRAFUJI Rika Kagoshima University, 農学部, プロジェクト研究員 (00549909)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Tomohide 鹿児島大学, 農学部, 准教授 (50383667)
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| Project Period (FY) |
2009 – 2010
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| Keywords | マダニ / オートファジー / オートファジー関連遺伝子 / 飢餓 / 寿命 / Target of rapamycin / ビテロジェニン |
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| Research Abstract |
Ticks are hematophagous arthropods and they can survive without food during the host-seeking period for several months to years. This study focused on autophagy which is induced during starvation in eukaryotes. Knockdown of autophagy-related genes and treatment with autophagy inhibitor led to a shortened life span in adult ticks. Tick autophagy might help compensate for the loss of nutrients derived from host blood components during the non-feeding period.
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