2010 Fiscal Year Final Research Report
Development of New Antiviral Therapy Targeting Viroporins
| Project/Area Number |
21890004
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
SUZUKI Tadaki National Institute of Infectious Diseases, 感染病理部, 任期付研究員 (30527180)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | JCウイルス / 進行性多巣性白質脳症 / Viroporin / Agnoprotein |
|---|
| Research Abstract |
Viroporins are a group of proteins interact with cellular membranes modifying permeability and which participate in the promotion of release of viral particles from infected cells. The JCV encoded agnoprotein, which is recognized as a viroporin recently, is essential for the viral replication. Here, we demonstrate that JCV viroporin, agnoprotein, interacts with the delta subunit of AP-3. This interaction prevents AP-3-mediated intracellular vesicular trafficking, resulting in plasma membrane permeabilization and facilitating virion release. Furthermore, the disruption of this interaction repressed both the viroporin activity and JC virus replication.
|
