2010 Fiscal Year Final Research Report
Trans-generational"memory" in Drosophila innate immunity
| Project/Area Number |
21890009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 自然免疫 / 遺伝子発現制御 / 遺伝学 |
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| Research Abstract |
To examine the existence of"trans-generational memory" in innate immunity, we used Drosophila melanogaster as a model system and did generational infection experiments. Gene expression profiling analyses revealed that some innate immunity-related gene expression patterns in response to a bacteria infection is significantly different between test group that has been infected at previous generations and the control group not infected previously. The results suggest the possibility that organism which only has innate immunity can"memorize" environmental stress, and that the"memory" can be maintained across generations.
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