2010 Fiscal Year Final Research Report
Role of stress-activated signaling pathway in mechanical stress-induced bone remodeling
| Project/Area Number |
21890014
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUI Hiroyuki Tohoku University, 加齢医学研究所, 教育研究支援者 (10547277)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 骨免疫学 / メカノバイオロジー / MAPキナーゼ |
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| Research Abstract |
Mechanical stress to bone is important for the maintenance of bone homeostasis. Osteoblast, which performs bone formation derived from mesenchymal cells, osteoclast which is responsible for bone resorption is hematopoietic stem cell origin like as other immune cells. Thus, osteoimmunological study is increasingly needed for the interpretation of osteoblast-osteoclast interaction. This study has unveiled that TAK1 MAPKKK was activated by mechanical stretch loading in osteoblast, and induced the expression of IL-6, an osteoclastogenic factor, via its downstream signaling pathway.
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