2010 Fiscal Year Final Research Report
Analysis of the role of Notch signal of NK cell in hematopoietic stem cell transplantation
| Project/Area Number |
21890027
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
KURITA Naoki University of Tsukuba, 附属病院, 病院講師 (30555561)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | Notch1 / GVHD / NK細胞 |
|---|
| Research Abstract |
The purpose of our study is to clarify roles of Notch signal of NK cell in graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation. Functionally mature NK cells were induced from human cord-blood CD34-positive cells by stimulation with Notch ligand. We established allogeneic stem cell transplantation GVHD model. Diminishment of GVHD was observed when Notch-induced NK cells were transfused into the recipient. It is revealed that NK cells of patients after hematopoietic stem-cell transplantation expressed Notch1 and intestinal epithelial cells, which are targets of GVHD, expressed Notch ligand, Jagged1. This result suggests the relation between Notch signal of NK cell and GVHD.
|
