2010 Fiscal Year Final Research Report
The analysis of host pathogen interaction in the intravesical BCG therapy
| Project/Area Number |
21890029
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MIYAZAKI Jun University of Tsukuba, 大学院・人間総合科学研究科, 講師 (10550246)
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| Project Period (FY) |
2009 – 2010
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| Keywords | BCG / 膀胱がん / 膀胱内注入療法 |
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| Research Abstract |
The induction of surface NKG2D ligands by R8-liposome-BCG-CWS rendered cancer cells more susceptible to cytolysis by lymphokine-activated killer cells. T24 bladder cancer cells, even when cultured singly in the absence of immune cells, can directly respond to R8-liposome-BCG-CWS. The results obtained in the present study may therefore indicate a novel adoptive immunotherapy against bladder cancers.
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[Journal Article] The liposome-incorporating cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guein can directly enhance the susceptibility of cancer cells to lymphokine-activated killer cells through up-regulation of natural-killer group2, member D ligands.2011
Author(s)
Miyazaki J, Kawai K, Kojima T, Oikawa T, Joraku A, Shimazui T, Nakaya A, Yano I, Nakamura T, Harashima H, Akaza H
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Journal Title
Peer Reviewed
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