2010 Fiscal Year Final Research Report
The influence of the anesthetics on cerebral nerve circuit construction in period of growth by visible of the GABAergic neurons
| Project/Area Number |
21890032
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
KUBO Kazuhiro Gunma University, 医学部, 助教 (80546531)
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| Project Period (FY) |
2009 – 2010
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| Keywords | GFP / GAD67 / 吸入麻酔薬 |
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| Research Abstract |
I administered 1.5% sevoflurane for each 12 hours on 1st day, 3rd day and 5th day after birth. After maturity, I examined teachability to go through a hippocampus, a base nucleus, a cerebral cortex, the cerebellum by Morris water maze test. As a result, the teachability of the sevoflurane treated group, the teachability of the sense of position in particular did not have a difference in comparison with the non-anesthesia group either.
Next, I examined Elevated plus maze test. As a result, the tendency that an anxiety behavior increased was seen with the sevoflurane treated group.
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