2010 Fiscal Year Final Research Report

Roles of brain K_<ATP> channels in the regulation of energy homeostasis

Research Project

Project/Area Number	21890034
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Environmental physiology (including Physical medicine and Nutritional physiology)
Research Institution	Chiba University
Principal Investigator	NAKAMURA Akira Chiba University, 大学院・医学研究院, 助教 (40343090)
Project Period (FY)	2009 – 2010
Keywords	ATP感受性K^+チャネル / 視床下部 / インスリンシグナル
Research Abstract	K_<ATP> channels in the brain participate in the regulation of energy homeostasis. In the present study, we examined the changes of neuropeptide expressions in the hypothalamus in response to fasting and systemic glucose administration. Unexpectedly, the regulation of neuropeptides in K_<ATP> channel knockout mice does not differ from that of wild type, suggesting that the brain K_<ATP> channels regulates energy homeostasis through a mechanism other than that involving neuropeptide expression in the hypothalamus.

(1 results)