2010 Fiscal Year Final Research Report
Roles of brain K_<ATP> channels in the regulation of energy homeostasis
| Project/Area Number |
21890034
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Chiba University |
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Principal Investigator |
NAKAMURA Akira Chiba University, 大学院・医学研究院, 助教 (40343090)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ATP感受性K^+チャネル / 視床下部 / インスリンシグナル |
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| Research Abstract |
K_<ATP> channels in the brain participate in the regulation of energy homeostasis. In the present study, we examined the changes of neuropeptide expressions in the hypothalamus in response to fasting and systemic glucose administration. Unexpectedly, the regulation of neuropeptides in K_<ATP> channel knockout mice does not differ from that of wild type, suggesting that the brain K_<ATP> channels regulates energy homeostasis through a mechanism other than that involving neuropeptide expression in the hypothalamus.
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