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2010 Fiscal Year Final Research Report

Roles of intraoral digestion on regulation of glucose metabolism

Research Project

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Project/Area Number 21890040
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionChiba University

Principal Investigator

KASAMATSU Atsushi  Chiba University, 医学部附属病院, 助教 (60375730)

Project Period (FY) 2009 – 2010
Keywords口腔内消化 / 糖代謝 / 生理学
Research Abstract

Intraoral digestion triggers various biological responses via taste sensation and/or nutrient absorption at upper intestine. Nevertheless, the effect of sweet sensation on the regulation of glucose metabolism remains unknown. We measured GLP-1 secretion in response to test meal ingestion in Japanese male volunteers. Unexpectedly, GLP-1 secretion occurred synchronously with blood glucose rise and non-nutritive sweetener failed to trigger GLP-1 secretion. Therefore, the early GLP-1 secretion requires the direct stimulation with nutrients in the gut rather than the sweet sensation on the tongue.

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Published: 2012-01-26   Modified: 2016-04-21  

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