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2010 Fiscal Year Final Research Report

Role of Asialoglycoprotein receptor in tumor microenvironment

Research Project

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Project/Area Number 21890044
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

HAYAKAWA Yoshihiro  The University of Tokyo, 大学院・薬学系研究科, 准教授 (10541956)

Project Period (FY) 2009 – 2010
Keywordsがん / 転移 / レクチン / 糖鎖 / シグナル伝達
Research Abstract

The importance of the interaction between endogenous lectins and glycans on cancer cells has been explored. In this study, we demonstrated that the importance of hepatic asialoglycoprotein receptor (ASGPR), C-type lectin with the preference in the recognition of galactose or N-acetylgalactosamine residue of the counter receptor, in the formation of metastasis of cancer cells.

  • Research Products

    (17 results)

All 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] The Interactions of Multiple Cytokines Control NK Cell Maturation.2010

    • Author(s)
      Brady J, Carotta S, Thong RP, Chan CJ, Hayakawa Y, Smyth MJ, Nutt SL
    • Journal Title

      The Journal of Immunology 185

      Pages: 6679-6688

    • Peer Reviewed
  • [Journal Article] Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules.2010

    • Author(s)
      Takeda K, Kojima Y, Uno T, Hayakawa Y, Teng MW, Yoshizawa H, Yagita H, Gejyo F, Okumura K, Smyth MJ
    • Journal Title

      The Journal of Immunology 184

      Pages: 5439-5501

    • Peer Reviewed
  • [Journal Article] Subset analysis of human and mouse mature NK cells.2010

    • Author(s)
      Hayakawa Y, Andrews DM, Smyth MJ
    • Journal Title

      Methods Mol.Biol. 612

      Pages: 27-38

    • Peer Reviewed
  • [Journal Article] In vivo imaging of obesity-induced inflammation in adipose tissue.2009

    • Author(s)
      Fushiki H, Hayakawa Y, Gomori A, Seo T, Tewari S, Ozaki S, Yoshimoto R
    • Journal Title

      Biochem Biophys Res Commun. 391

      Pages: 674-678

    • Peer Reviewed
  • [Journal Article] Quantification of mouse pulmonary cancer models by microcomputed tomography imaging.2009

    • Author(s)
      Fushiki H, Kanoh-Azuma T, Katoh M, Kawabata K, Jiang J, Tsuchiya N, Satow A, Tamai Y, Hayakawa Y
    • Journal Title

      Cancer Sci. 100

      Pages: 1544-1559

    • Peer Reviewed
  • [Journal Article] Reduction of autofluorescence of in vivo fluorescence imaging by using purified diet.2009

    • Author(s)
      Fushiki H, Hayakawa Y
    • Journal Title

      Nippon Yakurigaku Zasshi 134

      Pages: 13-16

    • Peer Reviewed
  • [Presentation] Tatsuro Irimura Evidences for cancer immune-escalation process and the role of inflammatory cytokines.2011

    • Author(s)
      早川芳弘
    • Organizer
      Keystone Symposia "Cancer Control by Tumor Suppressors and Immune Effectors"
    • Place of Presentation
      anta Fe Community Convention Center (Santa Fe, USA)
    • Year and Date
      2011-02-14
  • [Presentation] Requirement of endogenous IFN-gamma for effective recruitment of effector NK cells into tumor microenvironment.2010

    • Author(s)
      早川芳弘、佐藤まりも、田原秀晃、入村達郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-22
  • [Presentation] Phenotypic and functional diversity of mouse NK cells.2010

    • Author(s)
      早川芳弘
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2010-08-23
  • [Presentation] 入村達郎腫瘍微小環境へのNK細胞集積におけるIFN-γの重要性2010

    • Author(s)
      早川芳弘、佐藤まりも、田原秀晃
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      KKRホテル熊本(熊本)
    • Year and Date
      2010-07-22
  • [Presentation] 腫瘍微小環境へのNK細胞集積におけるIFN-γの重要性2010

    • Author(s)
      早川芳弘、入村達郎
    • Organizer
      第19回日本がん転移学会総会
    • Place of Presentation
      金沢市文化ホール(石川)
    • Year and Date
      2010-06-16
  • [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression and its implication in anti-tumor immune response.2009

    • Author(s)
      早川芳弘
    • Organizer
      39th Annual Scientific Meeting, Australasian Society for Immunology
    • Place of Presentation
      Cornard Jupiters (Gold Coast, Australia)
    • Year and Date
      2009-12-08
  • [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression, and its implication in anti-tumor immune response.2009

    • Author(s)
      早川芳弘
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-12-03
  • [Presentation] Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression and its implication in anti-tumor immune response.2009

    • Author(s)
      早川芳弘
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-02
  • [Presentation] マウスNK細胞サブッセットでの抑制性レセプターレパトア形成におけるMHC class Iの重要性と抗腫瘍免疫応答におけるその意義2009

    • Author(s)
      早川芳弘
    • Organizer
      第18回日本がん転移学会学術集会・総会
    • Place of Presentation
      旭川グランドホテル(旭川)
    • Year and Date
      2009-07-23
  • [Presentation] マウスNK細胞サブッセットでの抑制性レセプターレパトア形成におけるMHC class Iの重要性と抗腫瘍免疫応答におけるその意義2009

    • Author(s)
      早川芳弘
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州)
    • Year and Date
      2009-06-24
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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