2010 Fiscal Year Final Research Report
the behavior and role of naturally occurring and induced regulatory T cells in allergic airway inflammation
| Project/Area Number |
21890057
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IMAMURA Mitsuru The University of Tokyo, 保健・健康推進本部, 助教 (80529157)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 制御性T細胞 / 気道炎症 |
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| Research Abstract |
We analyzed the effect of naturally occurring regulatory T cells (nTregs) and induced regulatory T cells (iTregs) in allergic airway inflammation using gene-modified mice. Antigen specific iTregs were induced by airway inflammation, whereas airway inflammation was not changed by iTregs. On the other hand, the transfer of antigen-specific nTregs did not affect airway inflammation.
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