2010 Fiscal Year Final Research Report
Signaling pathway for interleukin-4 induction in basophils
| Project/Area Number |
21890092
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Shinshu University |
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Principal Investigator |
ODA Akihisa Shinshu University, 医学部, 研究員 (80547703)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 好塩基球 / アレルギー / IL-4 / PIR-B |
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| Research Abstract |
Although basophils produce IL-4 in response to IL-3, we discovered that basophils lost IL-3 responsiveness upon activation. PIR-B, the negative regulatory cell surface molecule is involved in the loss of IL-3 responses in activated basophils. In addition, PIR-B also negatively regulates IgG-induced IL-4 production in activated basophils. The inhibitory mechanisms by PIR-B required a cytoplasmic region in an unknown ITIM independent manner.
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