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2010 Fiscal Year Final Research Report

Reveal the mechanism of neocortical development by live imaging

Research Project

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Project/Area Number 21890096
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionNagoya University

Principal Investigator

SAKAKIBARA Akira  Nagoya University, 医学系研究科, 助教 (20510217)

Project Period (FY) 2009 – 2010
Keywords大脳皮質形成 / 細胞移動 / 細胞極性 / 細胞骨格 / イメージング
Research Abstract

In the present study, we have highlighted some critical points regarding the centrosome positioning in neocortical pyramidal neurons during the migration and axon/dendrite formation in situ. Major points are : 1) centrosome in migrating multipolar neurons moves toward the most dominantly growing process ; 2 leading centrosome is occasionally overtaken by rapidly translocating nucleus during a locomotion cycle ; 3) centrosome proximity appears not to be essential to the backward formation of an axon-like process by locomoting neurons.

  • Research Products

    (12 results)

All 2010 2009

All Journal Article (3 results) Presentation (9 results)

  • [Journal Article] early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior born Purkinje cells in the developing mouse lateral cerebellum.2010

    • Author(s)
      Miyata, T., Ono, Y., Okamoto, M., Masaoka, M., Sakakibara A., Kawaguchi, A., Hashimoto, M., Ogawa, M., Migration
    • Journal Title

      Neural Dev. 5

      Pages: 23

  • [Journal Article] Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis2010

    • Author(s)
      Wang, Y., Nakayama, M., Pitulescu, M.E., Schmidt, T.S., Bochenek, M.L., Sakakibara A., Adams, S., Davy, A., Deutsch, U., Barberis, A., Benjamin, L. E., Makinen, T., Nobes, C.D., Adams, R.H.
    • Journal Title

      Nature 465

      Pages: 483-486

  • [Journal Article] Rac is involved in the interkinetic nuclear migration of cortical progenitor cells.2009

    • Author(s)
      Minobe, S., Sakakibara A., Ohdachi, T., Kanda, R., Kimura, M., Nakatani, S., Tadokoro, R., Ochiai, W., Nishizawa, Y., Mizoguchi, A., Kawauchi, T., Miyata, T.
    • Journal Title

      Neurosci.Res. 63

      Pages: 294-301

  • [Presentation] Function of microtubule cytoskeleton in polarization of neocortical pyramidal neurons during the 3D migration and axon/dendrite formation in the developing mouse cerebrum.2010

    • Author(s)
      榊原明, 佐藤俊之, 正岡実, 宮田卓樹
    • Organizer
      The 50th American Society for Cell Biology Annual Meeting
    • Place of Presentation
      Pennsylvania Convention Center (USA)
    • Year and Date
      2010-12-14
  • [Presentation] Dynamics of centrosome and Golgi apparatus in neocortical pyramidal neurons during the transition of migration mode from multipolar to locomotion, and formation of axon-like fiber.2010

    • Author(s)
      榊原明, 佐藤俊之, 正岡実, 小川正晴, 宮田卓樹
    • Organizer
      The 40th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center (USA)
    • Year and Date
      2010-11-14
  • [Presentation] 大脳皮質錐体ニューロンの示す多極型からロコモーションへの移動モード転換と軸索様突起伸長開始過程における中心体、ゴルジ装置の細胞内動態2010

    • Author(s)
      榊原明、佐藤俊之、正岡実、小川正晴、宮田卓樹
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
  • [Presentation] 皮質板ニューロンに形成される一次樹状突起の形態的起源と動的変化:大脳皮質形成の実態2010

    • Author(s)
      榊原明、佐藤俊之、正岡実、小川正晴、宮田卓樹
    • Organizer
      第43回発生生物学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2010-06-22
  • [Presentation] マウス胎仔大脳皮質スライス培養を利用した錐体ニューロンの移動と軸索、樹状突起形成の動態解析2010

    • Author(s)
      榊原明、佐藤俊之、正岡実、小川正晴、宮田卓樹
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岩手県民会館(岩手県)
    • Year and Date
      2010-03-28
  • [Presentation] Live imaging the migration, axon/dendrite formation, and MTOC dynamics of cortical plate neurons under the 3D slice culture of embryonic mouse cerebrum.2009

    • Author(s)
      榊原明, 佐藤俊之, 正岡実, 小川正晴, 宮田卓樹
    • Organizer
      The 49th American Society for Cell Biology Annual Meeting
    • Place of Presentation
      San Diego Convention Center (USA)
    • Year and Date
      2009-12-07
  • [Presentation] ライブイメージングに基づくマウス大脳皮質層形成過程の解析2009

    • Author(s)
      榊原明、佐藤俊之、正岡実、小川正晴、宮田卓樹
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-09-18
  • [Presentation] Live imaging the cortical lamination in slice culture of embryonic mouse cerebrum.2009

    • Author(s)
      榊原明, 佐藤俊之, 正岡実, 小川正晴, 宮田卓樹
    • Organizer
      The 16th International Society of Developmental Biologists Congre ss
    • Place of Presentation
      Edinburgh International Conference Centre (UK)
    • Year and Date
      2009-09-08
  • [Presentation] マウス大脳皮質ニューロンの移動と層形成機構のin situイメージング解析2009

    • Author(s)
      榊原明、佐藤俊之、正岡実、宮田卓樹
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2009-06-03

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Published: 2012-01-26   Modified: 2016-04-21  

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