2010 Fiscal Year Final Research Report
Analysis of the regulatory mechanism of Lamin A degradation by RFP and its significance in malignant transformation.
| Project/Area Number |
21890097
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
KATO Takuya Nagoya University, 医学系研究科, 助教 (00551970)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Lamin A / RFP / Ubiquitin |
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| Research Abstract |
We found that Ret Finger Protein (RFP) catalyze the ubiquitination of Lamin A. We could not prove the degradation of Lamin A by ubiquitination as initially envisioned, however, we found that both RFP and Lamin A can positively regulate cancer cell migration. Therefore, our findings indicate another possibility that RFP regulates the Lamin A's function through its ubiquitination. Since there is no report that the mechanism regulates Lamin A through ubiquitination, our results preface the novel investigation of regulation of Lamin A.
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