Revealing the lung cancer mechanism using expression profile

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890099
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagoya University
• Principal Investigator: CHINATSU Arima Nagoya University, 大学院・医学系研究科, COE特任助教 (00534843)
• Project Period (FY): 2009 – 2010
• Keywords: 肺癌 / マイクロRNA / マイクロアレイ

Research Abstract

The aim of this study is to identify networks composed of mRNAs and miRNAs that show distinctive abnormality in the control of expression in the development of lung cancer. Thus, we extracted genes and miRNAs that are likely to directly regulate each other. As a result, we have found 10 pairs of miRNAs and their potential direct downstreams as well as 12 pairs of transcription factors and miRNAs of their potential targets. They included previously reported pairs including miR-29c and DNMT3A/DNMT3B as well as E2F8 and miR-18a. The regulatory interactions between the miRNAs and the coding genes are being experimentally validated.

Research Products

• [Journal Article] Identification of cancer metastasis-related gene that regulates multiple cellular stress response pathways thorough combined omics-approaches. (2010)
  • Author(s): Yanagisawa K, Konishi H, Arima C, Tomida S, Takeuchi T, Shimada Y, Yatabe Y, Mitsudomi T, Osada H, Takahashi T.
  • Journal Title: Cancer Res. 70(23) Pages: 9949-9958
  • Peer Reviewed
• [Journal Article] Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. (2010)
  • Author(s): Huang QM, Tomida S, Masuda Y,, Cao K, Kasahara TA, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M.
  • Journal Title: Cancer Res. 70(21) Pages: 8407-8416
  • Peer Reviewed
• [Journal Article] Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways : an international validation study. (2010)
  • Author(s): Bryant CM, Albertus DL, Kim S, Chen G, Brambilla C, Guedj M, Arima C, Travis WD, Yatabe Y, Takahashi T, Brambilla E, Beer DG.
  • Journal Title: PLoS One. 5(7) Pages: e11712
  • Peer Reviewed
• [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas.
  • Author(s): Matsuyama Y, Suzuki M, Arima C, Huang QM, Tomida S, Takeuchi T, Sugiyama R, Itoh Y, Yatabe Y, Goto H, Takahashi T.
  • Journal Title: Mol Carcinogenesis. in press
• [Presentation] 肺腺癌における潜在的治療標的としてのプロテアソーム非触媒サブユニットPSMD2 (2010)
  • Author(s): 有馬千夏, 松山恭士, 鈴木元, Miao Huang Qin, 谷田部恭, 後藤秀実, 高橋隆
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 大阪・大阪国際会議場
  • Year and Date: 20100900
• [Remarks] ホームページ等
  • URL: http://www.med.nagoya-u.ac.jp/medical/1710/1733/bunshisyuyougaku.html