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2010 Fiscal Year Final Research Report

Developing a novel therapy with umbilical cord blood cells for perinatal brain injuries

Research Project

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Project/Area Number 21890100
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Embryonic/Neonatal medicine
Research InstitutionNagoya University

Principal Investigator

SATO Yoshiaki  Nagoya University, 医学部附属病院, 助教 (30435862)

Project Period (FY) 2009 – 2010
Keywords臍帯血 / 周産期脳障害
Research Abstract

It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we have performed basic experiments for developing a novel therapy with human umbilical cord blood cells (HUCB), which is most ideal source of stem cells for perinatal brain injuries. After establishing a perinatal HI rat model, we evaluated the effect of administration of HUCB on perinatal HIE. We injected HUSB peritoneally after hypoxic-ischemic insult. The injected HUSB migrated into the brain, and tended to exert the anti-apoptotic and anti-oxidative effect, and increase the cell proliferation.

  • Research Products

    (24 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Carbohydrate and Energy Metabolism in the Brain of Rats with Thromboxane A2-Induced Fetal Growth Restriction.2011

    • Author(s)
      Hayakawa M, Sato Y, Hattori T, Ichinohashi Y, Nakayama A, Yamamoto H, Hemmi H, Miharu I, Ieda K, Kojima S.
    • Journal Title

      Pediatr Res in press

    • Peer Reviewed
  • [Journal Article] The diffusion weighted imaging for an early diagnosis of parasagittal injury.2010

    • Author(s)
      Tagaya M, Sato Y, Hayakawa M
    • Journal Title

      Pediatr Int 52(2)

      Pages: 298-301

    • Peer Reviewed
  • [Journal Article] Apoptosis-inducing factor deficiency decreases the proliferation rate and protects the subventricular zone against ionizing radiation.2010

    • Author(s)
      Osato K*, Sato Y(*equally contribution), Ochiishi T, Osato A, Zhu C, Sato M, Swanpalmer J
    • Journal Title

      Cell Death & Disease 1

      Pages: e84.4

    • Peer Reviewed
  • [Journal Article] Biological activities of highly sulfated chondroitin sulfate polysaccharides on neural cells.2010

    • Author(s)
      Nakanishi K, Sato Y, Oohira A.
    • Journal Title

      Research Advances in Neurochemistry, Global Research Network 1

      Pages: 1-10

  • [Journal Article] Chondroitin sulfate, a major niche substance of neuralstem cells, and cell transplantation therapy of neurodegeneration combined with niche modification.2009

    • Author(s)
      Sato Y, Oohira A.
    • Journal Title

      Curr Stem Cell Res Ther 4(3)

      Pages: 200-209

    • Peer Reviewed
  • [Journal Article] Male gender is related to the development of parenteral nutrition-associated cholestasis in neonates.2009

    • Author(s)
      Takemoto K, Nakayama A, Ito M, Sato Y, Saito A, Tori Y, Kaneko K, Ando H, Hayakawa M
    • Journal Title

      Journal of Neonatal-Perinatal Medicine 2(4)

      Pages: 247-251

    • Peer Reviewed
  • [Journal Article] Behavioral abnormalities of fetal growth retardation model rats with reduced amounts of brain proteoglycans.2009

    • Author(s)
      Saito A, Matsui F, Hayashi K, Watanabe K, Ichinohashi Y, Sato Y, Hayakawa M, Kojima S, Oohira A.
    • Journal Title

      Exp Neurol 219(1)

      Pages: 81-92

    • Peer Reviewed
  • [Journal Article] 早産重症胎児発育不全severe preterm FGR(IUGR)病因と病態 胎児発育不全モデルラットの中枢神経における組織学的および分子生物学的変化に関する研究2009

    • Author(s)
      早川昌弘, 中山淳, 竹本康二, 伊東真隆, 齊藤明子, 佐藤義朗
    • Journal Title

      周産期学シンポジウム 09(27)

      Pages: 37-42

  • [Journal Article] 【新生児の薬物療法】各疾患への薬物療法 新生児痙攣に対するフェノバルビタール療法2009

    • Author(s)
      佐藤義朗, 早川昌弘
    • Journal Title

      周産期医学 39(12)

      Pages: 1687-1690

  • [Journal Article] 新生児代表的疾患の基礎理解(第5回)脳室内出血(IVH)2009

    • Author(s)
      佐藤義朗
    • Journal Title

      こどもケア 4(5)

      Pages: 85-91

  • [Presentation] 未熟児網膜症に対する光凝固術施行時の鎮痛・鎮静2011

    • Author(s)
      佐藤義朗, 大城誠, 竹本康二, 細野治樹, 齊藤明子, 近藤大貴, 会津研二, 松沢麻衣子, 寺崎浩子, 早川昌弘
    • Organizer
      第29回周産期学シンポジウム
    • Place of Presentation
      佐賀
    • Year and Date
      20110114-20110115
  • [Presentation] 未熟児無呼吸治療/予防薬の神経幹細胞に対する細胞毒性および増殖に及ぼす影響2010

    • Author(s)
      佐藤義朗, 中西圭子, 伊藤美春, 一ノ橋祐子, 服部哲夫, 邊見勇人, 中山淳, 山本ひかる, 早川昌弘
    • Organizer
      第55回日本未熟児新生児学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20101105-20101107
  • [Presentation] ステロイドによる神経幹細胞の増殖と分化への影響2010

    • Author(s)
      一ノ橋祐子、佐藤義朗、服部哲夫、伊藤美春、山本ひかる、中山淳、早川昌弘
    • Organizer
      第55回日本未熟児新生児学会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20101105-20101107
  • [Presentation] Carbohydrate and Energy Metabolism in the Brain of Rats with Thromboxane2010

    • Author(s)
      Hayakawa M, Sato Y, Ichinohashi Y, Nakayama A, Yamamoto H, Hemmi H, Miharu I, Ieda K, Kojima.
    • Organizer
      A2 -Induced Fetal Growth RestrictionHot topics in Neonatology 2010
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      20101005-20101207
  • [Presentation] Apoptosis-inducing factor deficiency decreases the proliferation rate of neural precursor cells and protects the subventricular zone against ionizing radiation2010

    • Author(s)
      Sato Y, Osato K, Ochiishi T, Osato A, Zhu C, Sato M, Swanpalmer J, Modjtahedi N, Kroemer G, Kuhn GH, Blomgren K
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      20100902-20100904
  • [Presentation] Cerebral Maturation in Preterm SGA Infants2010

    • Author(s)
      Sato Y, Hattori T, Suzuki T, Hayashi N, Ito M, Hemmi H, Nakayama A, Yamamoto H, Ichinohashi Y, Hayakawa M
    • Organizer
      第46回日本周産期・新生児医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20100711-20100713
  • [Presentation] A simple scoring system using fetal MRI for prognosis in left congenital diaphragmatic hernia2010

    • Author(s)
      Hattori T, Sato Y, Itoh M, Tsuda H, Hemmi H, Sumigama S, Yamamoto H, Nakayama A, Kotani T, Hayakawa H, Hayakawa M
    • Organizer
      第46回日本周産期・新生児医学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      20100711-20100713
  • [Presentation] 中枢神経疾患に対する幹細胞療法 ~周産期脳障害の救世主となりうるか~2010

    • Author(s)
      佐藤義朗, 服部哲夫, 中西圭子, 大平敦彦, Klas Blomgren, 早川昌弘
    • Organizer
      第52回日本小児神経学会総会(シンポジウム)
    • Place of Presentation
      福岡
    • Year and Date
      20100520-20100522
  • [Presentation] 小児脳腫瘍における頭部放射線療法後の脳障害克服を目指して2010

    • Author(s)
      佐藤義朗
    • Organizer
      第562回九州大学生医研セミナー(多階層生体防御システム研究拠点)グローバルCOE理医連携セミナー(招待講演)
    • Place of Presentation
      福岡
    • Year and Date
      2010-12-02
  • [Presentation] Serial EEG findings in very premature infants born at gestational age of 22-23 weeks2009

    • Author(s)
      Hayakawa M., Sato Y., Nakayama A., Henmi H., Yamamoto H., Hattori T., Hayashi S., Tsuji T., Kato T., Hayakawa F., Kato Y., Takemoto K., Matsuzawa K., Kidokor H., Kubota T., Oshiro M
    • Organizer
      Hot Topics in Neonatology 2009
    • Place of Presentation
      Washington DC
    • Year and Date
      20091206-20091208
  • [Presentation] Neural stem/progenitor cells transplanted into the hippocampus of young mice survive and normalize behavior changes induced by irradiation2009

    • Author(s)
      Sato Y, Shinjyo N, Karlsson N, Nilsson M, Sato M, Oosato K, Zhu C, Kuhn HG, Pekny M, Pekna M, Blomgren K
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090916-20090918
  • [Presentation] 未熟児無呼吸治療/予防薬の神経幹細胞への影響2009

    • Author(s)
      佐藤義朗、中西圭子、早川昌弘
    • Organizer
      第45回日本周産期・新生児医学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      20090712-20090714
  • [Presentation] 在胎22・23週児における中枢神経受傷機序の解明 ~経時的脳波を用いた検討~2009

    • Author(s)
      佐藤義朗、服部哲夫、大城誠、加藤有一、城所博之、久保田哲夫、林誠司、加藤徹、松沢麻衣子、邊見勇人、山本ひかる、中山淳、早川昌弘
    • Organizer
      第54回日本未熟児新生児学会・学術集会(シンポジウム)
    • Place of Presentation
      横浜
    • Year and Date
      20090029-20091201
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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