2010 Fiscal Year Final Research Report
A possible mechanism of fructose-induced lipid synthesis for post translational modification of PGC-1β.
| Project/Area Number |
21890110
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
NAGAI Yoshio Shiga University of Medical Science, 医学部, 医員 (90402718)
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| Research Collaborator |
USHIO Masateru 滋賀医科大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2010
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| Keywords | 果糖 / 糖鎖 / メタボリックシンドローム / 栄養 |
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| Research Abstract |
The impact analysis using mouse liver tissue of high fructose feeding, revealed that O-GlcNAc proteins were increased after meal ingestion. These data suggest that increased hexosamine pathway might be associated with the development of metabolic syndrome. Furthermore, fructose may activate a transcription factor, ChREBP which was known to respond to glucose.
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