Exploring the kinase-independent role of IKKβ

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890115
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Kyoto University
• Principal Investigator: ASHIDA Noboru Kyoto University, 医学研究科, 助教 (00538978)
• Project Period (FY): 2009 – 2010
• Keywords: 炎症 / 循環器

Research Abstract

We have identified several proteins which physically interact with IKKβ and they are possibly regulated by it in kinase-independent manner. Also we have found some proteins which have been reported to have close connection with atherosclerosis or cancer are regulated by some anti-inflammatory drugs.

Research Products

• [Journal Article] IKK β regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. (2011)
  • Author(s): Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Shi Yin Foo, Matthew Coggins, Joel A. Spencer, Parisa Zamiri, Dongxiao Shen, Ling Li, Tracey Sciuto, Ann Dvorak, Robert E. Gerszten, Charles P. Lin, Michael Karin, Anthony Rosenzweig.
  • Journal Title: Corresponding Authors : Anthony Rosenzweig and Noboru Ashida doi:10.1038/ncomms1317 Pages: 2-318
  • Peer Reviewed
• [Presentation] IKK β regulates Akt activation in kinase-independent manner in endothelial cells (2009)
  • Author(s): Noboru Ashida, Sucharita SenBanerjee, Shohta Kodama, Joel A.Spencer, Parisa Zamiri, Ling Li, Robert E.Gerszten, Charles P.Lin, Michael Karin, Anthony Rosenzweig, Masayuki Yokode.
  • Organizer: 第41回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 於下関メッセ
  • Year and Date: 2009-07-17