2010 Fiscal Year Final Research Report
Research for a novel mechanism of prostate cancer progression using a newly established xenograft model
| Project/Area Number |
21890120
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIMIZU Yosuke Kyoto University, 医学研究科, 助教 (00542094)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 前立腺癌 / Xenograft / アンドロゲン受容体変異 / ホルモン不応性 |
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| Research Abstract |
We established a novel xenograft mouse model mimicking a human prostate cancer. Immunohistochemistry showed AR and PSA protein expression in epithelial cells. Sequencing analysis revealed the AR with a point mutation at amino acid 874 (H874Y). Promoter assay revealed agonistic effect of estradiol against the AR with apoint mutation H874Y.
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