2010 Fiscal Year Final Research Report
Regulation of transcription factors and neuronal development by necdin-Sirt1 complex
| Project/Area Number |
21890123
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
HASEGAWA Koichi Osaka University, たんぱく質研究所, 助教 (20546783)
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| Project Period (FY) |
2009 – 2010
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| Keywords | エネルギー代謝 / 摂食 / 肥満 / 体温調節 / アセチル化 / 視床下部 / 脳神経疾患 |
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| Research Abstract |
Necdin is a positive regulator of Sirt1 protein deacetylase. In this study, I focused Foxo1 that is related for feeding. Necdin-Sirt1 complex deacetylased Foxo1 and modified thermoregulation through controlling neuropeptides and thyroid hormones.
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