2010 Fiscal Year Final Research Report
Analysis of the induction and activation of intestinal Th17 cells
| Project/Area Number |
21890127
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The University of Tokyo (2010)
Osaka University (2009) |
|---|
Principal Investigator |
ATARASHI KOJI The University of Tokyo, 大学院・医学系研究科, 特任助教 (60546787)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | Th17細胞 / Treg細胞 / 腸内細菌 |
|---|
| Research Abstract |
Th17 cells, one of T helper subsets, secrete interleukin-17 (IL-17), IL-17F, and IL-22 and have significant roles in protecting the host from bacterial and fungal infections, as well as autoimmune diseases. I have demonstrated that Th17 cells are abundant in intestinal mucosa and Th17 cell accumulation in gut is induced by segmented filamentous bacteria (SFB). At the same time, the accumulation of regulatory T cells (Tregs) in gut is mediated by Clostridium species.
|
