2010 Fiscal Year Final Research Report

Case-control study for lifestyle related risk factors of early spontaneous abortions

Research Project

Project/Area Number	21890128
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Public health/Health science
Research Institution	Osaka University
Principal Investigator	BABA Sachiko Osaka University, 大学院・医学系研究科, 特任助教(常勤) (90532987)
Project Period (FY)	2009 – 2010
Keywords	初期流産 / 早期流産 / 生活習慣 / 喫煙 / 就労 / 日本
Research Abstract	In this matched case-control study, we investigated the associations of reproductive and lifestyle characteristics of women with early spontaneous abortion <12 weeks of gestation. Information was collected through medical records for 430 cases of early spontaneous abortion and 860 controls of term delivery. Two controls were individual-matched to one case according to maternal age (+/-3 years) and calendar year of events (either early spontaneous abortion or delivery). Multivariable conditional odds ratios (ORs) and 95% confidence interval (CI) were calculated with conditional logistic-regression. The risk of early spontaneous abortions was higher for women with a past history of early spontaneous abortions. Maternal smoking and employment also influence risk. Our finding suggests that for Japanese women, smoking and working may be important public health issue targets for the prevention of early spontaneous abortions.