2010 Fiscal Year Final Research Report
The study of susceptibility genes loci to diabetes mellitus.
| Project/Area Number |
21890129
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
UEDA Hironori Osaka University, 大学院・医学系研究科, 特任准教授(常勤) (90543463)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 糖尿病の遺伝素因 / 発症原因遺伝子 / Tリンパ球 / TGF-β1 / Zac1 / NSYマウス |
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| Research Abstract |
Type 1 Diabetes (T1D) of man and animal models results from immune-mediated specific beta cell destruction. Putative transforming growth factor-β1 regulated T1D susceptibility genes were identified by using T lymphoma cell-lines in this study. A question how these genes can determine T1D susceptibility by regulating T lymphocytes and T lymphocyte recognition in immunological synapse still remains unsolved and will be addressed.
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