2010 Fiscal Year Final Research Report

Analysis of anticancer drug-resistant ovarian cancer cells under hypoxic tumor microenvironment

Research Project

Project/Area Number	21890130
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Osaka University
Principal Investigator	HAYASHI Masami Osaka University, 医学系研究科, 助教 (00551748)
Project Period (FY)	2009 – 2010
Keywords	卵巣癌 / 抗癌剤耐性 / Akt / mTOR
Research Abstract	Paclitaxel-resistant ovarian cancer cells showed the activation of Akt and significantly higher levels of Akt2 expression compared with paclitaxel-sensitive cells. An HIF-2α expression was also higher in paclitaxel-resistant cells than in paclitaxel-sensitive cells. We next examined the significance of Akt2 in paclitaxel-resistant in vivo tumor growth by selectively inhibiting Akt2. An siRNA targeting Akt2 inhibited ovarian tumor growth in nude mice. These results indicated molecular target treatment against either Akt2 or HIF-2α would be useful for the paclitaxel-resistant ovarian cancer.

(4 results)