2010 Fiscal Year Final Research Report
A study on antibiotic resistance of Porphyromonas gingivalis biofilm
| Project/Area Number |
21890133
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAGUCHI Mikiyo Osaka University, 歯学部附属病院, 医員 (30523089)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 歯学 / バイオフィルム / 抗菌剤 / ポルフィロモナス ジンジバリス / 菌体外マトリックス |
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| Research Abstract |
In this study, I showed that chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC) were effective against Porphyromonas gingivalis cells in biofilm, but extracellular matrix remained in biofilm after CHX and CPC application. In addition, extracellular matrix remained after CHX application was difficult to eliminate mechanically, suggesting that remaining extracellular matrix provides a scaffold for biofilm reformation.
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