2010 Fiscal Year Final Research Report

Development of a novel method of promoting alveolar bone formation by controlling the expression of BMP antagonist.

Research Project

Project/Area Number	21890149
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Okayama University
Principal Investigator	FUJISAWA Takuo Okayama University, 岡山大学病院, 助教 (20325096)
Project Period (FY)	2009 – 2010
Keywords	質細胞 / BMP / BMPアンタゴニスト / siRNA
Research Abstract	The purpose of this study is to identify the BMP antagonists which expressed during osteogenic differentiation induced by BMP-2 and develop a novel method for promoting alveolar bone formation by controlling the expression of those antagonists. In this study, I demonstrate knockdown of SOST by RNA interference in vitro resulted in a significant increase in the expression of the osteogenic marker alkaline phosphatase and the deposition of extracellular mineral, in response to osteogenic stimulation.

(1 results)