2010 Fiscal Year Final Research Report
Clarification in regulatory expression mechanism of lubrication functional protein SZP and therapeutic development of temporomandibular joint
| Project/Area Number |
21890163
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAMIYA Takashi Hiroshima University, 医薬学総合研究科, 特任助教 (40551057)
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| Project Period (FY) |
2009 – 2010
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| Keywords | SZP / サイトカイン / 機械的負荷 / 摩擦係数 |
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| Research Abstract |
It was suggested that SZP is regulated by growth factor and cytokine. Overloading may cause the reduction of the SZP expression and increase the frictional coefficient as the result of mechanical stress-induced cytokines. From these results, it was suggested SZP is involved in the first stage of cartilage degradation.
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