2010 Fiscal Year Final Research Report

Non-invasive estimation of input function in ultra-rapid CBF/CMRO2 measurement

Research Project

Project/Area Number	21890171
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	Kagawa University
Principal Investigator	KUDOMI Nobuyuki Kagawa University, 医学部, 准教授 (20552045)
Project Period (FY)	2009 – 2010
Keywords	脳酸素代謝 / 脳血流 / PET / 入力関数 / 動態解析
Research Abstract	The Purpose of the present study is to develop a non-invasive method for obtaining cerebral blood flow (CBF) and oxygen metabolism (CMRO_2) in rapid PET measurement. In the present approach, a model function was introduced to express a shape and scale of input function, and then tissue response curves for water and oxygen, respectively, was calculated, i.e., model tissue curves were obtained. The model tissue curves were fitted to the measured multiple brain tissue curves and obtained parameters for the model function reconstructed the input functions. In the measured data, the accuracy of CBF and CMRO_2 were 13% using the non-invasive procedure. Also, simulation showed that the accuracy for the present method is around 10%. All these findings supported that the present method would of use for CBF and CMRO_2 PET examination.

(4 results)