2010 Fiscal Year Final Research Report
Development of molecular imaging probes applied for multimodality
| Project/Area Number |
21890179
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
SANO Kohei Kyushu University, 薬学研究科, 特定助教 (00546476)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射線 / 分子認識 / 薬学 |
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| Research Abstract |
We established a radiolabeled γ-polyglutamic acid (γ-PGA) complex as a nanocarrier for molecular imaging with high cell uptake and low toxicity. This ^<111> In labeled PGA complex with strong anionic surface showed low cytotoxicity, indicating the high biocompatiblility. ^<111> In-PGA complex exhibited the high uptake by macrophage. Moreover, ^<111> In-PGA complex clearly visualized the sentinel lymph node (SLN) with single photon emission computed tomography (SPECT), suggesting that ^<111> In-PGA complex is useful as a SLN imaging probe with low cytotoxicity.
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