2010 Fiscal Year Final Research Report
Study for the pathogenesis of Small -for-Size Syndrome after living donor liver transplantation
| Project/Area Number |
21890180
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
NINOMIYA Mizuki Kyushu University, 大学病院, 特任助教 (30546461)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 過小グラフト / 生体肝移植 |
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| Research Abstract |
Suppression of MEK/ERK signaling pathway in the early phase after hepatectomy resulted in gradual regenerative response and ameliorated the prognosis of rats after critical hepatic volume reduction as a consequence of coordinated replication of hepatocytes and sinusoidal endothelial cells. Among 334 liver transplant recipients, 41 patients developed postoperative septic complications, and their 1-year survival rates were significantly worse than those without sepsis. In a multivariate analysis, small graft syndrome and delayed enteral nutrition were selected as independent risk factors for development of postoperative septic complications.
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