Elucidation of inhibition mechanism of ameloblastoma growth・ differentiation by Sprouty regulating MAPK cascade.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890185
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu University
• Principal Investigator: TAKETOMI Takaharu Kyushu University, 大学院・歯学研究院, 助教 (10553290)
• Project Period (FY): 2009 – 2010
• Keywords: MAPK / Sprouty / EGF / FGF 刺激 / エナメル上皮腫

Research Abstract

expression were enhanced by EGF stimulation. Spry2 induced by Ras-ERK signal cascade was negative regulator for ERK activation by FGF signaling, but accelerated it by EGF signaling in AM-1 cells. Spry2 might be associated with the growth of ameloblastoma through the promotion of EGF signaling.

Research Products

• [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling. (2011)
  • Author(s): Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S.
  • Journal Title: Biochem Biophys Res Commun. Volume 404, Issue 4 Pages: 1076-1082
• [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate. (2010)
  • Author(s): K.Matsumura, T.Taketomi, K.Yoshizaki, D.Yoshiga, T.Maehara, S.Arai, T.Sanui, A.Yoshimura, S.Nakamura.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-16
• [Presentation] RNF135, a RING finger protein, negatively regulates RAS/MAPK signaling. (2010)
  • Author(s): D.Yoshiga, T.Taketomi, D.Muratsu, T.Onimura, H.Shiraishi, T.Sanada, T.Kobayashi, S.Nakamura.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-16
• [Presentation] Suppression of Sprouty2 Induces Periodontal Tissue Regeneration. (2010)
  • Author(s): T.Sanui, T.Fukuda, T.Taketomi, T.Hamachi, K.Maeda.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-16
• [Presentation] Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation. (2010)
  • Author(s): Takaharu Taketomi, Daigo yoshiga, Kaori matsumura, Takeshi Mitsuyasu, Terukazu Sanui, Takao Fukuda, Akihiko Yoshimura, Seiji Nakamura.
  • Organizer: 88th General Session and Exhibition of the IADR
  • Year and Date: 2010-07-15
• [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate. (2010)
  • Author(s): Kaori Matsumura, Takaharu taketomi, Masaaki Sasaguri, Takeshi Mitsuyasu, Tomomi Tsujiguchi, Shinsaku Arai, Daigo Yoshiga, Terukazu Sanui, Akihiko Yoshimura, Seiji Nakamura.
  • Organizer: The 6th Congress of International Cleft Palate Foundation in Conjunction with 14th national Congress of Korean Cleft Lip and Palate Association
  • Year and Date: 2010-06-10
• [Presentation] Analysis of the molecular mechanisms of periodontal regeneration by EMD. (2010)
  • Author(s): Takao Fukuda, Terukazu Sanui, Takaharu Taketomi, Takafumi Hamachi, Katsumasa Maeda.
  • Organizer: The 5th International Symposum on Dental and Craniofacial Morphogenesis and Tissue Regeneration : A View from Stem Cell Research
  • Year and Date: 2010-02-05
• [Remarks] ホームページ等