2010 Fiscal Year Final Research Report
Establishment of mouse model of carcinomatous peritonitis for tailor maid cancer therapy.
| Project/Area Number |
21890191
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
KANETAKA Kengo Nagasaki University, 病院, 助教 (10549570)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 胃癌 / 癌性腹膜炎 / 動物モデル |
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| Research Abstract |
Cancer stem cell marker CD44 expression in T3/4 gastric cancer.
We investigated the correlation between expression of CD44 and clinicopathological factors such as carcinomatous peritonitis in patients with advanced T3/4 gastric adenocarcinoma. Present study did not show any correlation between the expression of CD44, known cancer stem cell marker, and clinicopathological factors. However, even among patients with advanced (T3-4) gastric adenocarcinoma, CD44 positive group showed poorer prognosis than CD44 negative one. These results suggested that CD44, putative cancer stem cell marker, might be involved in tumor progression, although the precise mechanism remains to be elucidated.
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