Common roles of macrophage proliferation and polarization in type 2 diabetes and atherosclerosis.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890197
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: SENOKUCHI Takafumi Kumamoto University, 大学院・生命科学研究部, 特任助教 (00530320)
• Co-Investigator(Renkei-kenkyūsha): YAMAGATA Kazuya 熊本大学, 大学院・生命科学研究部, 教授 (70324770) ; MATSUMURA Takeshi 熊本大学, 大学院・生命科学研究部, 助教 (20398192) ; KOMOHARA Yoshihiro 熊本大学, 大学院・生命科学研究部, 助教 (40449921)
• Project Period (FY): 2009 – 2010
• Keywords: 2型糖尿病 / 動脈硬化 / マクロファージ

Research Abstract

Inflammatory M1 macrophage infiltration into pancreatic islets
in diabetic model db/db was significantly increased, which suggested the implication of M1 macrophage in b cell dysfunction in type 2 diabetes. We generated the transgenic mouse containing p27 cDNA under the control of scavenger receptor promoter, which is macrophage-specific proliferation restricted mouse. However both male and female of this mutant mouse were infertile. The p27 mRNA expression was significantly increased in bone marrow-derived macrophage from Tg mice, and the proliferation of these macrophages were restricted. The effect of p27 expression in macrophage on infertility will be another project to be studied farther.