2010 Fiscal Year Final Research Report
Common roles of macrophage proliferation and polarization in type 2 diabetes and atherosclerosis.
Project/Area Number |
21890197
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | Kumamoto University |
Principal Investigator |
SENOKUCHI Takafumi Kumamoto University, 大学院・生命科学研究部, 特任助教 (00530320)
|
Co-Investigator(Renkei-kenkyūsha) |
YAMAGATA Kazuya 熊本大学, 大学院・生命科学研究部, 教授 (70324770)
MATSUMURA Takeshi 熊本大学, 大学院・生命科学研究部, 助教 (20398192)
KOMOHARA Yoshihiro 熊本大学, 大学院・生命科学研究部, 助教 (40449921)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 2型糖尿病 / 動脈硬化 / マクロファージ |
Research Abstract |
Inflammatory M1 macrophage infiltration into pancreatic islets in diabetic model db/db was significantly increased, which suggested the implication of M1 macrophage in b cell dysfunction in type 2 diabetes. We generated the transgenic mouse containing p27 cDNA under the control of scavenger receptor promoter, which is macrophage-specific proliferation restricted mouse. However both male and female of this mutant mouse were infertile. The p27 mRNA expression was significantly increased in bone marrow-derived macrophage from Tg mice, and the proliferation of these macrophages were restricted. The effect of p27 expression in macrophage on infertility will be another project to be studied farther.
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