2010 Fiscal Year Final Research Report
The development of novel cancer-immunotherapy utilizing dendritic cells derived from iPS cells.
| Project/Area Number |
21890199
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
FUKUSHIMA Satoshi Kumamoto University, 医学部附属病院, 助教 (50398210)
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| Project Period (FY) |
2009 – 2010
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| Keywords | iPS細胞 / 樹状細胞 / 癌免疫療法 |
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| Research Abstract |
To develop the novel cell-vaccine against the advanced malignant melanoma, we conducted the experiments using the genetically modified iPS cell derived dendritic cells. We found that the dendritic cells could be generated from any clones of mouse iPS cells. We found that KIF20A is highly expressed in malignant melanoma. In addition, we found that micro RNA-221 could be a new tumor marker of malignant melanoama.
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[Journal Article] The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker.2011
Author(s)
Kanemaru H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H.
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Journal Title
J Dermatol Sci. 61巻
Pages: 187-193
Peer Reviewed
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[Journal Article] Circulating microRNA associated with TNF-α signaling pathway in patients with plaque psoriasis.2011
Author(s)
Oyama R, Jinnin M, Kakimoto A, Kanemaru H, Ichihara A, Fujisawa A, Honda N, Masuguchi S, Fukushima S, Maruo K, Ihn H.
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Journal Title
J Dermatol Sci. 61巻
Pages: 209-211
Peer Reviewed
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[Journal Article] Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis.2010
Author(s)
Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.
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Journal Title
Arthritis Res Ther. 12巻
Pages: R128
Peer Reviewed
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