2010 Fiscal Year Final Research Report
Novel treatment strategy of type 2 diabetes focused on beta cell mass
| Project/Area Number |
21890213
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Yokohama City University |
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Principal Investigator |
NAKAMURA Akinobu Yokohama City University, 附属病院, 助教 (70552420)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 膵β細胞量 / グルコキナーゼ / 妊娠 |
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| Research Abstract |
We investigated the effect of glucokinase activator (GKA) on beta cell function and proliferation. Glucokinase activation by GKA increased expression levels of IRS-2 and cell cycle signaling molecules. GKA was able to stimulate beta cell proliferation independently of insulin stimulation and stimulate beta cell function independently of IRS-2. Also, our results raise the possibility that GKA do not work well under excessive oxidative stress in beta cells.
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