2010 Fiscal Year Final Research Report
Identification of flavonoids-binding proteins, and basic research of cancer prevention based on molecular mechanisms
| Project/Area Number |
21890223
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IIZUMI Yosuke Kyoto Prefectural University of Medicine, 医学研究科, 助教 (20533178)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ケミカルバイオロジー / ナノ磁性ビーズ / フラボノイド / アピゲニン / 癌予防 / 標的分子 / 作用機序 / プロテオミクス |
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| Research Abstract |
A number of flavonoids in food are believed to have cancer chemopreventive activity. This research identified flavonoids-binding proteins by utilizing nano-magnetic beads and MALDI-TOF MS. Moreover, it was clarified that apigenin-binding protein 1 (ABP1) regulated the G2 phase of the cell cycle, and apigenin inhibited the proliferation of HT-29 cells by inhibiting ABP1. This achievement is the first evidence that explains thecancer chemopreventive activity of flavonoids from flavonoids-binding proteins.
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