2010 Fiscal Year Final Research Report
Development of custom-made virus therapy for gastric cancer using gene expressing oncolytic virus
| Project/Area Number |
21890231
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
TSUJI Toshiaki Wakayama Medical University, 医学部, 学内助教 (20549737)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 癌 / 腫瘍融解性ウイルス / 発現制御 |
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| Research Abstract |
Therapies for unresectable advanced and recurrent gastric cancer have been unsatisfactory. New therapies using oncolytic viruses have been expected. These viruses have mutations on their genes and only replicate in tumor cells, but these mutated genes sometimes spoil their oncolytic ability. To enhance their oncolysis, various attempts have been done. In this study, we selected appropriate gene for individual gastric cancer and construct virus expressing that gene to enhance oncolysis. Immunohistochemical study revealed gene expression of individual gastric cancer and therapeutic experiments were undergone and enhanced therapeutic effects were observed.
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[Journal Article] Clinicopathological characteristics of remnant gastric cancer after a distal gastrectomy.2010
Author(s)
Ojima T, Iwahashi M, Nakamori M, Nakamura M, Naka T, Katsuda M, Iida T, Tsuji T, Hayata K, Takifuji K, Yamaue H
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Journal Title
J.Gastrointest Surg. 14
Pages: 277-281
Peer Reviewed
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