2010 Fiscal Year Final Research Report
The role of EDHF-mediated responses under pathological conditions
| Project/Area Number |
21890233
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
GOTO Kenichi Kyushu Dental College, 歯学部, 助教 (30549887)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 内皮機能 / 内皮由来過分極因子 / 一酸化窒素 / 食塩感受性高血圧 |
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| Research Abstract |
High salt diet up-regulates EDHF-mediated relaxation through the activation of BKCa in mesenteric arteries of Dahl salt-sensitive hypertensive rats. Up-regulation of EDHF compensates for the loss of NO to maintain overall endothelial function in salt-sensitive hypertension.
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