Elucidation of physiological role of the bone formation potentiator contained in platelet.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890243
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Saitama Medical University
• Principal Investigator: OHTE Satoshi Saitama Medical University, 医学部, 助教 (00547979)
• Project Period (FY): 2009 – 2010
• Keywords: 骨代謝 / 血小板 / Bone morphogenetic protein / Smad

Research Abstract

The aim of this study is to elucidate the physiological role of the bone formation potentiator contained in platelet. As a result, it became clear that this protein increase the activity of bone morphogenetic protein (BMP), which is the cytokine induce ectopic bone formation in muscular tissue, in vitro and in vivo. Our findings suggest that this protein will become new medicine of bone formation.

Research Products

• [Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H (2011)
  • Author(s): Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T
  • Journal Title: Biochem Biophys Res Commun. 407 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase. (2011)
  • Author(s): Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, Katagiri T
  • Journal Title: Mol Endocrinol. 25 Pages: 474-481
  • Peer Reviewed
• [Journal Article] Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3beta-dependent and beta-catenin-independent mechanism. (2010)
  • Author(s): Fukuda T, Kokabu S, Ohte S, Sasanuma H, Kanomata K, Yoneyama K, Kato H, Akita M, Oda H, Katagiri T
  • Journal Title: Differentiation. 80 Pages: 46-52
  • Peer Reviewed
• [Journal Article] Dual roles of smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins. (2010)
  • Author(s): Nojima J, Kanomata K, Takada Y, Fukuda T, Kokabu S, Ohte S, Takada T, Tsukui T, Yamamoto TS, Sasanuma H, Yoneyama K, Ueno N, Okazaki Y, Kamijo R, Yoda T, Katagiri T
  • Journal Title: J Biol Chem 285 Pages: 15577-15586
  • Peer Reviewed
• [Journal Article] Protein phosphatase magnesium-dependent 1A-mediated inhibition of BMP signaling is independent of Smad dephosphorylation. (2010)
  • Author(s): Kokabu S, Nojima J, Kanomata K, Ohte S, Yoda T, Fukuda T, Katagiri T
  • Journal Title: J Bone Miner Res. 25 Pages: 653-660
  • Peer Reviewed
• [Presentation] Identification of Zranb2, a novel R-Smads binding protein, as a suppressor of BMP signaling. (2010)
  • Author(s): Satoshi Ohte, Shoichiro Kokabu, Toru Fukuda,, Shunichiro Iemura, Hiroki Sasanuma, Katsumi Yoneyama, Masashi Shin, Eijiro Jimi, Toru Natsume, Takenobu Katagiri
  • Organizer: 2010 ASBMR Annual Meeting
  • Place of Presentation: トロント(カナダ)
  • Year and Date: 2010-10-17
• [Presentation] Platelet Factor 4 is a novel potentiator of BMP-induced osteoblastic differentiation and bone formation. (2010)
  • Author(s): Takenobu Katagiri, Toru Fukuda, Akihiro Tomoyasu, Masaaki Goto, Kunihiko Kodaira, Shoichiro Kokabu, Satoshi Ohte, 他18名
  • Organizer: 2010 ASBMR Annual Meeting
  • Place of Presentation: トロント(カナダ)
  • Year and Date: 2010-10-17
• [Presentation] Identification and characterization of a nuclear protein as a co-suppressor of BMP-regulated R-Smads. (2010)
  • Author(s): Satoshi Ohte, Shoichiro Kokabu, Toru Fukuda, Shunichiro Iemura, Hiroki Sasanuma, Katsumi Yoneyama, Masashi Shin, Eijiro Jimi, Toru Natsume, Takenobu Katagiri
  • Organizer: 8th International BMP Conference
  • Place of Presentation: ルーベン(ベルギー)
  • Year and Date: 2010-09-15
• [Presentation] 新規R-Smad結合分子ZRANB2のBMPシグナル阻害活性 (2010)
  • Author(s): 大手聡、古株彰一郎、福田亨、笹沼寛樹、米山克美、進正史、自見英治郎、片桐岳信
  • Organizer: 第28回日本骨代謝学会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] 骨芽細胞におけるSmadとRunx2のクロストーク (2009)
  • Author(s): 大手聡、福田亨、古株彰一郎、片桐岳信
  • Organizer: 第7回RCGMフロンティアシンポジウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-11-03
• [Remarks] ホームページ等
  • URL: http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html