2010 Fiscal Year Final Research Report

The analysis of AMPK-mTOR signaling pathway

Research Project

Project/Area Number	21890244
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	General medical chemistry
Research Institution	Kitasato University
Principal Investigator	TATSUHIRO Sato Kitasato University, 薬学部, 助教 (70547893)
Project Period (FY)	2009 – 2010
Keywords	シグナル伝達 / mTOR / AMPK / プロテオーム
Research Abstract	AMPK-mTOR signaling pathway plays an important role in the regulation of cellular energy. Although dysregulation of mTOR activity is observed in many types of cancer cells, the precise mechanism remains unclear. In this research, we performed a comprehensive analysis of the proteins expressed in cultured cells and found novel proteins involved in AMPK-mTOR signaling pathway. Our studies provide a new mechanism of AMPK-mTOR signaling pathway and will contribute to the development of new anti-cancer drugs.

(3 results)