2010 Fiscal Year Final Research Report
Regulation mechanisms of the placental barrier for the maintenance of the fetal environment and their relevancies to the phenotype
Project/Area Number |
21890246
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Keio University |
Principal Investigator |
TOMI Masatoshi Keio University, 薬学部, 講師 (30334717)
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Project Period (FY) |
2009 – 2010
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Keywords | 胎盤関門 / トランスポーター / 発現制御 |
Research Abstract |
The placental barrier regulates fetal transfer of maternal substances and thus maintains fetal environment. Therefore, it is important to elucidate functional regulations at the placental barrier. In this study, we clarified regulations of transporter expression at the placental barrier by (1) differentiation to the placental barrier, (2) gestational diabetes, and (3) caloric restriction. These results represent that the molecular expression at the placental barrier are regulated by placental differentiation and maternal nutrition environment in order to maintain fetal environment.
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Research Products
(13 results)
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[Journal Article] Proton-coupled erythromycin antiport at rat blood-placenta barrier2010
Author(s)
Y.Sai, T.Nishimura, K.Ochi, N.Tanaka, A.Takagi, M.Tomi, N.Kose, Y.Kobayashi, N.Miyakoshi, S.Kitagaki, C.Mukai, E.Nakashima
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Journal Title
Drug Metab.Dispos. 38
Pages: 1576-1581
Peer Reviewed
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