Elucidation of the mechanism of immunosuppression by mesenchymal stem cells in cancer microenvironments

2010 Fiscal Year Final Research Report

• Project/Area Number: 21890247
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Keio University
• Principal Investigator: YAGUCHI Tomonori Keio University, 医学部, 助教 (40424163)
• Project Period (FY): 2009 – 2010
• Keywords: 間葉系幹細胞 / 腫瘍免疫回避 / がん免疫療法

Research Abstract

In this study, we evaluated the immunological roles of mesenchymal stem cells (MSC) in cancer microenvironment. GFP chimeric mouse models showed that bone marrow-derived MSC migrated to caner tissues and augmented the tumor growth. Human MSC inhibited dendritic cells functions through the production of a variety of immunosuppressive cytokines such as IL6 and VEGF. These results suggested that MSC induced caner immune evasion in the cancer microenvironment and can be an attractive target for the restoration of immune competence of cancer patients.

Research Products

• [Journal Article] The mechanisms of cancer immunoescape and development of overcoming strategies. (2011)
  • Author(s): Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, Iwata-Kajihara T, Nishio H, Kawamura N, Kawakami Y.
  • Journal Title: Int J Hematol 93 Pages: 294-300
  • URL: http://www.springerlink.com/content/c478p246673x144p/fulltext.pdf
  • Peer Reviewed
• [Journal Article] Emerging concepts in biomarker discovery ; The US-Japan workshop on immunological molecular markers in oncology. (2009)
  • Author(s): Tahara H, Yaguchi T, et al.
  • Journal Title: J Transl Med. 7 Pages: 45
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/19534815
  • Peer Reviewed
• [Presentation] Immune escape of human melanoma via activated Wnt/β-catenin signaling. (2010)
  • Author(s): Yaguchi T, Goto Y, Kido K, Mochimaru H, Sakurai T, Tsukamoto N, Kudo-Saito C, Fujita T, Sumimoto H, Kawakami Y.
  • Organizer: 14^<th> International Congress of Immunology 2010
  • Place of Presentation: Kobe International Convention Center
  • Year and Date: 2010-08-25
• [Presentation] シンポジウム2「次世代がん免疫療法の開発に向けた基礎・応用研究「がん免疫逃避機構とその制御」 (2010)
  • Author(s): 河上裕、住本秀敏、工藤千恵、塚本信夫、植田良、梶原知子、川村直,谷口智憲,
  • Organizer: 第14回日本がん免疫学会
  • Place of Presentation: KKRホテル熊本
  • Year and Date: 2010-07-23
• [Presentation] MAPK signaling is a potential target for improvement of immunotherapy through reversal of immunosuppressive tumor microenvironment. (2009)
  • Author(s): 谷口智憲、岩田-梶原知子、川村直、工藤-斉藤千恵、住本秀敏、河上裕
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20091202-20091204