2010 Fiscal Year Final Research Report
Analysis of membrane-associated calcium-independent phospholipase A_2 (iPLA_<2γ>) in vivo.
| Project/Area Number |
21890254
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
YODA Emiko Showa University, 薬学部, 助教 (60527183)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脂質 / ホスホリパーゼA2 / ミトコンドリア / 筋肉組織 / 血小板 / 脂肪細胞 |
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| Research Abstract |
In this study, we analyzed about iPLA_<2γ> gene knockout mice to investigate that the function of iPLA_<2γ> in vivo. We found that iPLA_<2γ> knockout mice showed remarkable phenotypes, growth retardation and muscle weakness. We further found that compositions of caldiolipin, a critical mitochondrial phospholipid, and other phospholipid subclasses were altered.
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[Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of group VIB Ca^<2+>-independent phospholipase A_2 (iPLA_2{gamma}) deficient mice.2010
Author(s)
Yoda E., Hachisu K., Taketomi Y., Yoshida K., Nakamura M., Ikeda K., Taguchi R., Nakatani Y., Kuwata H., Murakami M., Kudo I., Hara, S.
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Journal Title
J.Lipid Res. 51
Pages: 3003-3015
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[Remarks] ホームページ等
