2010 Fiscal Year Final Research Report
Mood disorders associated with latent herpes virus infection in the brain.
| Project/Area Number |
21890260
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KOBAYASHI Nobuyuki Jikei University School of Medicine, 医学部, 助教 (20385321)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 気分障害 / ヒトヘルペスウイルス6 / 動物モデル / うつ病 / 双極性障害 / アストロサイト / SITH-1 / 慢性疲労症候群 |
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| Research Abstract |
In the present study, we have aimed to clarify the connection between the Small protein encoded by the Intermediate stage Transcript of HHV-6 (SITH)-1 and mood disorders. SITH-1 significantly up-regulated the intracellular calcium levels. An increase in calcium levels is generally thought to be an important factor in mood disorders. When we caused SITH-1 to be expressed in mouse brain glial cells, the mouse showed manic-like behavior and depressive-like behavior. These results suggest that SITH-1 is involved in the onset of mood disorders.
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