2010 Fiscal Year Final Research Report
Functional analysis of stress-response protein in the mouse brain
| Project/Area Number |
21890263
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
UMEMURA Mariko Tokyo University of Pharmacy and Life Science, 生命科学部, 助教 (30521489)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳 / 転写因子 / ストレス応答 |
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| Research Abstract |
ATF5 is a stress-response transcription factor. The physiological role of ATF5 was investigated by the generation of ATF5-deficient mice. The ATF5-deficient mice showed abnormal brain morphology and 70% of these mice died within three days of birth. ATF5-knockdown caused an inhibition of neurite outgrowth in migrating neurons of the cerebral cortex. Furthermore, we found that ATF5(-/-) male mice exhibited reduced aggressiveness toward intruders.
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[Journal Article] Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells2010
Author(s)
Yamazaki T, Ohmi A, Kurumaya H, Kato K, Abe T, Yamamoto H, Nakanishi N, Okuyama R, Umemura M, Kaise T, Watanabe R, Okawa Y, Takahashi S, Takahashi Y
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Journal Title
Life Sci. 28
Pages: 294-301
Peer Reviewed
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[Remarks] ホームページ等
