2010 Fiscal Year Final Research Report
ADAM22 localization mechanism and myelin formation at the Axon.
| Project/Area Number |
21890269
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
OGAWA Yasuhiro Meiji Pharmaceutical University, 薬学部, 助教 (00531948)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遺伝子 / 神経科学 / 脳・神経 |
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| Research Abstract |
The purpose of this study was to analyze the function of ADAM22 in the neuronal axonal side. We found new interacting molecules with ADAM22, and showed that these molecules associate with ADAM22. Our data suggest that ADAM22 modulate ion-channel activity in neurons.
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[Journal Article] ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.2010
Author(s)
Ogawa Y., Oses-Prieto J., Kim M.Y., Horresh I., Peles E., Burlingame A.L., Trimmer J.S., Meijer D., Rasband M.N.
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Journal Title
Journal of Neuroscience 30
Pages: 1038-1048
Peer Reviewed
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