2010 Fiscal Year Final Research Report

Involvement of TRPC channels in sympathetically-regulated bone metabolism

Research Project

Project/Area Number	21890276
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Functional basic dentistry
Research Institution	Aichi Gakuin University
Principal Investigator	KODAMA Daisuke Aichi Gakuin University, 歯学部, 助教 (40549979)
Project Period (FY)	2009 – 2010
Keywords	交感神経 / 骨芽細胞 / イオンチャネル
Research Abstract	By using patch clamp methods, effects of noradrenaline on ion channels were investigated in human osteoblast, SaM-1. The results in this study indicated that noradrenaline inhibited K channels via α1B-adrenergic receptors. The effect was independent of protein kinase C and intracellular Ca^<2+> concentration. This suggested that G_q protein-coupled receptor was not involved in the effect. This study will aid our understanding of the mechanism behind the regulation of bone metabolism by the sympathetic nervous system.

(4 results)