2010 Fiscal Year Final Research Report
Carcinogenesis caused by tobacco and alcohol for human tongue keratinocytes (HTK) cell line
| Project/Area Number |
21890287
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
SEGAWA Emi Hyogo College of Medicine, 医学部, 助教 (00553778)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 口腔癌 / HPV / 発癌 |
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| Research Abstract |
To elucidate the carcinogenesis process, we newly established human tongue keratinocytes (HTK) cell lines derived from tongue mucosa immortalized by infection with retroviral vectors expression HPV16 E6/E7. Furthermore, treatment of HPV16 E6/E7 with NNK and EtOH in vitro, and HTK1-16E6E7-NNK + EtOH was established. Then we examined a change of the cell biology in both cells and identified the responsibility gene in the carcinogenesis in oral squamous cell carcinoma.
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